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KMID : 0882419880350060766
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Korean Journal of Medicine
1988 Volume.35 No. 6 p.766 ~ p.774
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Bone MINERAL Density in Graves Disease an dMyxedema
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Jeon Geun-Jae
Lim Sung-Kil
Lee Hyun-Chul
Kim Kyung-Rae
Huh Kap-Bum
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Abstract
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We studied 59 patients who had received a diagnosis of graves’ disease or myxedema by dual photon absor-ptiometry from August 1986 to July 1987 at the Depart-ment of Internal Medicine, Yonsei University Severance Hospital. The results were summarized as follows: 1) Patients with Graves’ disease of a mean duration of 19.2 weeks demonstrated an average of 9.37 mg/dl Ca and 4.29 mg/dl P in their blood samples while the 24 hr urine specimen showed 194.26 mg/dl 24 hr of Ca and the P revealed 520.36 mg/24 hr, which is higher than those of myxedema. 2) The patients with Graves’ disease revealed a prevalence of osteoporosis in the following, Ward’s triangle 18.8%, femoral neck 20.8%, trochanter 25%, but the spine, while observed at 22.9% in hyperthyroidism, also was detected at 18.2% in myxedema. 3) In females with Graves’ disease, the values of BMD were relatively lower than those of the control group but showed a greater attraction to osteoporosis than the males.
4) Most womon in their postmonopaunal poriod showed a strong tondency to develop osteoporosis in the femoral neek but they demonstrated a greater relation-ship to the spine. 5) Even after treatment, the BMD revealed a ten-dency to continue increasing, however, there was still a possibility for incomplete recovery. Excess thyroid hormones lead to negative bone min-eral balance, The revealed bone loss was clinically significant in postmenopausal women despite its short dyratuib abd ut aooeared ti be at keast oartuakkt reversubke after treatment.
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KEYWORD
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Key Words: Graves’ disease, myxedema, bone den-sity, osteopenia
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